Kuo-Hsuan Chang Selected Research

glycyrrhizae radix et rhizoma

1/2021	Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement.
1/2019	Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
1/2018	Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.

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Kuo-Hsuan Chang Research Topics

Disease

22	Parkinson Disease (Parkinson's Disease) 04/2022 - 02/2004
15	Alzheimer Disease (Alzheimer's Disease) 07/2022 - 07/2009
11	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2022 - 01/2013
10	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2020 - 01/2013
7	Neuroinflammatory Diseases 04/2022 - 01/2018
7	Huntington Disease (Huntington's Disease) 12/2017 - 01/2012
6	Stroke (Strokes) 01/2020 - 01/2010
5	Multiple Sclerosis 10/2020 - 07/2009
4	Disease Progression 04/2022 - 01/2019
4	Inflammation (Inflammations) 01/2021 - 01/2018
4	Guillain-Barre Syndrome 01/2018 - 05/2007
4	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/2018 - 05/2007
3	Neuroblastoma 07/2022 - 01/2021
3	Atrial Fibrillation 01/2022 - 01/2020
3	Hemorrhage 01/2022 - 01/2020
3	Neuromyelitis Optica (Devic's Disease) 10/2020 - 02/2013
3	Dementia (Dementias) 06/2019 - 08/2018
3	Atrophy 07/2016 - 08/2013
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 06/2014
2	Cerebral Hemorrhage 01/2022 - 01/2015
2	Neoplasms (Cancer) 11/2021 - 01/2021
2	Ischemic Stroke 01/2020 - 01/2018
2	Amyloid Plaque 12/2018 - 02/2016
2	Miller Fisher Syndrome (Fisher Syndrome) 10/2016 - 07/2009
2	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 06/2014 - 01/2013
2	Diplopia (Double Vision) 01/2014 - 07/2013
2	Viral Meningitis 07/2009 - 05/2007
1	AIDS-Related Complex (ARC) 07/2022
1	Pain (Aches) 07/2022
1	Gastrointestinal Hemorrhage (Hematochezia) 01/2022
1	Cognitive Dysfunction 01/2022
1	Epilepsy (Aura) 01/2022
1	Seizures (Absence Seizure) 01/2022
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2021

Drug/Important Bio-Agent (IBA)

14	polyglutamineIBA 11/2020 - 01/2012
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2012
10	Biomarkers (Surrogate Marker)IBA 04/2022 - 02/2015
7	Amyloid (Amyloid Fibrils)IBA 01/2021 - 02/2016
6	SynucleinsIBA 04/2022 - 03/2016
5	EnzymesIBA 01/2017 - 05/2007
4	Phosphotransferases (Kinase)IBA 07/2022 - 01/2013
4	tau Proteins (tau Protein)IBA 01/2021 - 01/2016
4	tributyl phosphate (TBP)IBA 01/2020 - 01/2014
4	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2020 - 01/2014
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2022 - 04/2007
3	Interleukin-6 (Interleukin 6)IBA 04/2022 - 10/2016
3	AnticoagulantsIBA 01/2022 - 01/2020
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/2021 - 06/2007
3	Pharmaceutical PreparationsIBA 01/2021 - 10/2018
3	glycyrrhizae radix et rhizomaIBA 01/2021 - 01/2018
3	indoleIBA 01/2019 - 10/2014
3	ImmunosorbentsIBA 02/2013 - 05/2007
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2022 - 11/2021
2	Biological ProductsIBA 07/2022 - 01/2012
2	Vitamin K FDA Link 01/2022 - 01/2020
2	Antidepressive Agents (Antidepressants)IBA 01/2022 - 09/2005
2	N(4)-oleylcytosine arabinosideIBA 01/2022 - 01/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2019
2	Leucine (L-Leucine)FDA Link 01/2021 - 01/2013
2	AntioxidantsIBA 11/2020 - 10/2018
2	Topiramate (Topamax)FDA LinkGeneric 01/2020 - 10/2015
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 09/2005
2	Lactulose (Duphalac)FDA LinkGeneric 01/2020 - 01/2020
2	HLA-DR Antigens (HLA-DR)IBA 01/2020 - 01/2020
2	MelibioseIBA 01/2020 - 01/2020
2	CytokinesIBA 01/2019 - 01/2018
2	Huntingtin ProteinIBA 11/2017 - 01/2016
2	Prealbumin (Transthyretin)IBA 01/2017 - 07/2009
2	GlucocorticoidsIBA 01/2014 - 07/2013
2	HaptoglobinsIBA 02/2013 - 05/2007
1	Glycogen Synthase (Synthase I)IBA 07/2022
1	polyvinylidene fluoride (PVDF)IBA 07/2022
1	trifluoroetheneIBA 07/2022
1	GraphiteIBA 07/2022
1	C-Reactive ProteinIBA 04/2022
1	InterleukinsIBA 04/2022
1	Interleukin-2 (IL2)IBA 04/2022
1	Interleukin-10 (Interleukin 10)IBA 04/2022
1	Chemokine CCL5IBA 04/2022
1	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 04/2022
1	Bupropion (Wellbutrin)FDA LinkGeneric 01/2022
1	Risperidone (Risperdal Consta)FDA LinkGeneric 01/2022
1	TECAIBA 01/2022
1	Antipsychotic Agents (Antipsychotics)IBA 01/2022
1	Haloperidol (Haldol)FDA LinkGeneric 01/2022
1	OrnithineIBA 01/2022
1	SphingolipidsIBA 01/2022
1	Quetiapine Fumarate (Seroquel)FDA Link 01/2022
1	Serotonin and Noradrenaline Reuptake InhibitorsIBA 01/2022
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2022
1	apixabanIBA 01/2022
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022
1	Paroxetine (Paxil)FDA LinkGeneric 01/2022
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2022
1	Chlorpromazine (Thorazine)FDA Link 01/2022
1	Prochlorperazine (Compazine)FDA LinkGeneric 01/2022
1	Serotonin (5 Hydroxytryptamine)IBA 01/2022
1	Therapeutic UsesIBA 12/2021

Therapy/Procedure

7	Therapeutics 01/2022 - 09/2006
1	Thyroidectomy 11/2021